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Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM50380049
Substrate
n/a
Meas. Tech.
ChEMBL_810738 (CHEMBL2015971)
IC50
40±n/a nM
Citation
 Mougenot, P; Namane, C; Fett, E; Camy, F; Dadji-Faïhun, R; Langot, G; Monseau, C; Onofri, B; Pacquet, F; Pascal, C; Crespin, O; Ben-Hassine, M; Ragot, JL; Van-Pham, T; Philippo, C; Chatelain-Egger, F; Péron, P; Le Bail, JC; Guillot, E; Chamiot-Clerc, P; Chabanaud, MA; Pruniaux, MP; Schmidt, F; Venier, O; Nicolaï, E; Viviani, F Thiadiazoles as new inhibitors of diacylglycerol acyltransferase type 1. Bioorg Med Chem Lett 22:2497-502 (2012) [PubMed]  Article 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:
Protein
Mol. Mass.:
55297.82
Organism:
Homo sapiens (Human)
Description:
O75907
Residue:
488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
  
Inhibitor
Name:
BDBM50380049
Synonyms:
CHEMBL2012611
Type:
Small organic molecule
Emp. Form.:
C25H33N3O3S
Mol. Mass.:
455.613
SMILES:
OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)C(=O)Nc1nnc(CCC2CCCCC2)s1 |r,wU:7.10,wD:4.3,(15.04,-25.76,;13.5,-25.78,;12.74,-27.12,;12.71,-24.46,;11.17,-24.48,;10.38,-23.15,;8.84,-23.17,;8.09,-24.52,;8.87,-25.84,;10.41,-25.82,;6.56,-24.54,;5.77,-23.22,;4.24,-23.24,;3.49,-24.57,;4.27,-25.89,;5.81,-25.88,;1.95,-24.59,;1.17,-23.26,;1.19,-25.93,;-.35,-25.95,;-1.27,-24.71,;-2.72,-25.21,;-2.71,-26.75,;-4.05,-27.5,;-5.38,-26.72,;-6.72,-27.47,;-8.04,-26.68,;-9.38,-27.44,;-9.4,-28.98,;-8.06,-29.76,;-6.73,-29,;-1.24,-27.21,)|
Structure:
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