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Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM50380050
Substrate
n/a
Meas. Tech.
ChEMBL_810738 (CHEMBL2015971)
IC50
44±n/a nM
Citation
 Mougenot, P; Namane, C; Fett, E; Camy, F; Dadji-Faïhun, R; Langot, G; Monseau, C; Onofri, B; Pacquet, F; Pascal, C; Crespin, O; Ben-Hassine, M; Ragot, JL; Van-Pham, T; Philippo, C; Chatelain-Egger, F; Péron, P; Le Bail, JC; Guillot, E; Chamiot-Clerc, P; Chabanaud, MA; Pruniaux, MP; Schmidt, F; Venier, O; Nicolaï, E; Viviani, F Thiadiazoles as new inhibitors of diacylglycerol acyltransferase type 1. Bioorg Med Chem Lett 22:2497-502 (2012) [PubMed]  Article 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:
Protein
Mol. Mass.:
55297.82
Organism:
Homo sapiens (Human)
Description:
O75907
Residue:
488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
  
Inhibitor
Name:
BDBM50380050
Synonyms:
CHEMBL2012622
Type:
Small organic molecule
Emp. Form.:
C24H24FN3O4S
Mol. Mass.:
469.528
SMILES:
OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)C(=O)Nc1nnc(COc2ccc(F)cc2)s1 |r,wU:7.10,wD:4.3,(44.91,-18.68,;43.37,-18.7,;42.62,-20.04,;42.59,-17.38,;41.05,-17.39,;40.26,-16.07,;38.72,-16.09,;37.97,-17.44,;38.75,-18.76,;40.29,-18.74,;36.44,-17.45,;35.65,-16.14,;34.11,-16.16,;33.36,-17.49,;34.14,-18.81,;35.69,-18.8,;31.82,-17.51,;31.04,-16.18,;31.07,-18.85,;29.53,-18.87,;28.61,-17.63,;27.15,-18.12,;27.16,-19.67,;25.82,-20.42,;24.5,-19.64,;23.15,-20.39,;21.83,-19.6,;20.49,-20.36,;20.47,-21.9,;19.13,-22.66,;21.81,-22.68,;23.14,-21.92,;28.63,-20.13,)|
Structure:
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