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Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM50380048
Substrate
n/a
Meas. Tech.
ChEMBL_810738 (CHEMBL2015971)
IC50
45±n/a nM
Citation
 Mougenot, P; Namane, C; Fett, E; Camy, F; Dadji-Faïhun, R; Langot, G; Monseau, C; Onofri, B; Pacquet, F; Pascal, C; Crespin, O; Ben-Hassine, M; Ragot, JL; Van-Pham, T; Philippo, C; Chatelain-Egger, F; Péron, P; Le Bail, JC; Guillot, E; Chamiot-Clerc, P; Chabanaud, MA; Pruniaux, MP; Schmidt, F; Venier, O; Nicolaï, E; Viviani, F Thiadiazoles as new inhibitors of diacylglycerol acyltransferase type 1. Bioorg Med Chem Lett 22:2497-502 (2012) [PubMed]  Article 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:
Protein
Mol. Mass.:
55297.82
Organism:
Homo sapiens (Human)
Description:
O75907
Residue:
488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
  
Inhibitor
Name:
BDBM50380048
Synonyms:
CHEMBL2012629
Type:
Small organic molecule
Emp. Form.:
C24H24FN3O3S
Mol. Mass.:
453.529
SMILES:
OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)C(=O)Nc1nnc(Cc2ccccc2F)s1 |r,wU:7.10,wD:4.3,(42.15,-8.67,;40.61,-8.69,;39.86,-10.04,;39.82,-7.37,;38.28,-7.39,;37.49,-6.06,;35.96,-6.08,;35.21,-7.43,;35.99,-8.75,;37.52,-8.74,;33.67,-7.45,;32.89,-6.13,;31.35,-6.15,;30.6,-7.49,;31.38,-8.8,;32.92,-8.79,;29.06,-7.5,;28.28,-6.18,;28.31,-8.84,;26.77,-8.86,;25.85,-7.63,;24.39,-8.12,;24.4,-9.66,;23.06,-10.41,;21.74,-9.63,;21.76,-8.09,;20.43,-7.31,;19.09,-8.06,;19.08,-9.61,;20.4,-10.39,;20.39,-11.93,;25.87,-10.12,)|
Structure:
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