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Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM50380047
Substrate
n/a
Meas. Tech.
ChEMBL_810739 (CHEMBL2015972)
IC50
57±n/a nM
Citation
 Mougenot, P; Namane, C; Fett, E; Camy, F; Dadji-Faïhun, R; Langot, G; Monseau, C; Onofri, B; Pacquet, F; Pascal, C; Crespin, O; Ben-Hassine, M; Ragot, JL; Van-Pham, T; Philippo, C; Chatelain-Egger, F; Péron, P; Le Bail, JC; Guillot, E; Chamiot-Clerc, P; Chabanaud, MA; Pruniaux, MP; Schmidt, F; Venier, O; Nicolaï, E; Viviani, F Thiadiazoles as new inhibitors of diacylglycerol acyltransferase type 1. Bioorg Med Chem Lett 22:2497-502 (2012) [PubMed]  Article 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:
Protein
Mol. Mass.:
55297.82
Organism:
Homo sapiens (Human)
Description:
O75907
Residue:
488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
  
Inhibitor
Name:
BDBM50380047
Synonyms:
CHEMBL2012631
Type:
Small organic molecule
Emp. Form.:
C24H24ClN3O3S
Mol. Mass.:
469.984
SMILES:
OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)C(=O)Nc1nnc(Cc2cccc(Cl)c2)s1 |r,wU:7.10,wD:4.3,(44.73,-17.98,;43.19,-18,;42.43,-19.34,;42.4,-16.67,;40.86,-16.69,;40.07,-15.37,;38.53,-15.39,;37.78,-16.74,;38.57,-18.05,;40.1,-18.04,;36.25,-16.75,;35.47,-15.43,;33.93,-15.46,;33.18,-16.79,;33.96,-18.11,;35.5,-18.09,;31.64,-16.81,;30.86,-15.48,;30.88,-18.15,;29.34,-18.16,;28.42,-16.93,;26.96,-17.42,;26.98,-18.96,;25.64,-19.72,;24.31,-18.93,;24.33,-17.39,;23.01,-16.61,;21.67,-17.36,;21.66,-18.91,;20.32,-19.67,;22.98,-19.69,;28.45,-19.42,)|
Structure:
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