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Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM50380052
Substrate
n/a
Meas. Tech.
ChEMBL_810738 (CHEMBL2015971)
IC50
65±n/a nM
Citation
 Mougenot, P; Namane, C; Fett, E; Camy, F; Dadji-Faïhun, R; Langot, G; Monseau, C; Onofri, B; Pacquet, F; Pascal, C; Crespin, O; Ben-Hassine, M; Ragot, JL; Van-Pham, T; Philippo, C; Chatelain-Egger, F; Péron, P; Le Bail, JC; Guillot, E; Chamiot-Clerc, P; Chabanaud, MA; Pruniaux, MP; Schmidt, F; Venier, O; Nicolaï, E; Viviani, F Thiadiazoles as new inhibitors of diacylglycerol acyltransferase type 1. Bioorg Med Chem Lett 22:2497-502 (2012) [PubMed]  Article 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:
Protein
Mol. Mass.:
55297.82
Organism:
Homo sapiens (Human)
Description:
O75907
Residue:
488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
  
Inhibitor
Name:
BDBM50380052
Synonyms:
CHEMBL2012613
Type:
Small organic molecule
Emp. Form.:
C23H29N3O3S
Mol. Mass.:
427.56
SMILES:
OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)C(=O)Nc1nnc(CCC2CCC2)s1 |r,wU:7.10,wD:4.3,(13.19,-35.05,;11.65,-35.07,;10.9,-36.41,;10.87,-33.74,;9.33,-33.76,;8.54,-32.44,;7,-32.46,;6.25,-33.81,;7.03,-35.13,;8.57,-35.11,;4.72,-33.82,;3.93,-32.51,;2.4,-32.53,;1.65,-33.86,;2.42,-35.18,;3.97,-35.16,;.11,-33.88,;-.68,-32.55,;-.65,-35.22,;-2.19,-35.23,;-3.11,-34,;-4.57,-34.49,;-4.55,-36.03,;-5.89,-36.79,;-7.22,-36,;-7.2,-34.46,;-6.1,-33.39,;-7.18,-32.29,;-8.28,-33.36,;-3.08,-36.49,)|
Structure:
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