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Target
Prolyl endopeptidase FAP
Ligand
BDBM50382288
Substrate
n/a
Meas. Tech.
ChEMBL_816255 (CHEMBL2026780)
IC50
2400±n/a nM
Citation
 Ryabtsova, O; Jansen, K; Van Goethem, S; Joossens, J; Cheng, JD; Lambeir, AM; De Meester, I; Augustyns, K; Van der Veken, P Acylated Gly-(2-cyano)pyrrolidines as inhibitors of fibroblast activation protein (FAP) and the issue of FAP/prolyl oligopeptidase (PREP)-selectivity. Bioorg Med Chem Lett 22:3412-7 (2012) [PubMed]  Article 
Target
Name:
Prolyl endopeptidase FAP
Synonyms:
Fap | Fibroblast activation protein (FAP) | SEPR_MOUSE | Seprase
Type:
Enzyme
Mol. Mass.:
87949.14
Organism:
Mus musculus (Mouse)
Description:
P97321
Residue:
761
Sequence:
MKTWLKTVFGVTTLAALALVVICIVLRPSRVYKPEGNTKRALTLKDILNGTFSYKTYFPNWISEQEYLHQSEDDNIVFYNIETRESYIILSNSTMKSVNATDYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLQNGEFVRGYELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITYTGRENRIFNGIPDWVYEEEMLATKYALWWSPDGKFLAYVEFNDSDIPIIAYSYYGDGQYPRTINIPYPKAGAKNPVVRVFIVDTTYPHHVGPMEVPVPEMIASSDYYFSWLTWVSSERVCLQWLKRVQNVSVLSICDFREDWHAWECPKNQEHVEESRTGWAGGFFVSTPAFSQDATSYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAIYIFRVTQDSLFYSSNEFEGYPGRRNIYRISIGNSPPSKKCVTCHLRKERCQYYTASFSYKAKYYALVCYGPGLPISTLHDGRTDQEIQVLEENKELENSLRNIQLPKVEIKKLKDGGLTFWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVKSVFAVNWITYLASKEGIVIALVDGRGTAFQGDKFLHAVYRKLGVYEVEDQLTAVRKFIEMGFIDEERIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASIYSERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGISSGRSQNHLYTHMTHFLKQCFSLSD
  
Inhibitor
Name:
BDBM50382288
Synonyms:
CHEMBL2024673
Type:
Small organic molecule
Emp. Form.:
C15H17N3O3
Mol. Mass.:
287.3138
SMILES:
COc1cccc(c1)C(=O)NCC(=O)N1CCC[C@H]1C#N |r|
Structure:
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