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Target
Tyrosine-protein phosphatase non-receptor type 12
Ligand
BDBM46264
Substrate
n/a
Meas. Tech.
ChEMBL_855962 (CHEMBL2161836)
IC50
>40000±n/a nM
Citation
 Stanford, SM; Krishnamurthy, D; Falk, MD; Messina, R; Debnath, B; Li, S; Liu, T; Kazemi, R; Dahl, R; He, Y; Yu, X; Chan, AC; Zhang, ZY; Barrios, AM; Woods, VL; Neamati, N; Bottini, N Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells. J Med Chem 54:1640-54 (2011) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 12
Synonyms:
PTN12_HUMAN | PTP-PEST | PTPG1 | PTPN12 | Protein-tyrosine phosphatase G1 | Tyrosine-protein phosphatase non-receptor type 12 | Tyrosine-protein phosphatase non-receptor type 12 (PTP-PEST)
Type:
Protein
Mol. Mass.:
88089.78
Organism:
Homo sapiens (Human)
Description:
Q05209
Residue:
780
Sequence:
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVNEINTENMVSSIEPEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSEQHSADLNRNYSKSTELPGKNESTIEQIDKKLERNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASPCIADKISKPQELSSDLNVGDTSQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHGPENAIPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVETPDLVDHDNTSPLFRTPLSFTNPLHSDDSDSDERNSDGAVTQNKTNISTASATVSAATSTESISTRKVLPMSIARHNIAGTTHSGAEKDVDVSEDSPPPLPERTPESFVLASEHNTPVRSEWSELQSQERSEQKKSEGLITSENEKCDHPAGGIHYEMCIECPPTFSDKREQISENPTEATDIGFGNRCGKPKGPRDPPSEWT
  
Inhibitor
Name:
BDBM46264
Synonyms:
3-[2-azaspiro[5.5]undecan-2-yl-(1-cyclopentyl-1,2,3,4-tetrazol-5-yl)methyl]-6-methyl-1H-quinolin-2-one | 3-[2-azaspiro[5.5]undecan-2-yl-(1-cyclopentyl-5-tetrazolyl)methyl]-6-methyl-1H-quinolin-2-one | 3-[2-azaspiro[5.5]undecan-2-yl-(1-cyclopentyltetrazol-5-yl)methyl]-6-methyl-1H-quinolin-2-one | 3-[2-azaspiro[5.5]undecan-2-yl-(1-cyclopentyltetrazol-5-yl)methyl]-6-methyl-carbostyril | MLS-0412204.0001 | cid_3182456
Type:
Small organic molecule
Emp. Form.:
C27H36N6O
Mol. Mass.:
460.6143
SMILES:
Cc1ccc2[nH]c(=O)c(cc2c1)C(N1CCCC2(CCCCC2)C1)c1nnnn1C1CCCC1
Structure:
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