Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 1
Ligand
BDBM50399256
Substrate
n/a
Meas. Tech.
ChEMBL_876919 (CHEMBL2184947)
IC50
88±n/a nM
Citation
 Cavallaro, CL; Briceno, S; Chen, J; Cvijic, ME; Davies, P; Hynes, J; Liu, RQ; Mandlekar, S; Rose, AV; Tebben, AJ; Van Kirk, K; Watson, A; Wu, H; Yang, G; Carter, PH Discovery and lead optimization of a novel series of CC chemokine receptor 1 (CCR1)-selective piperidine antagonists via parallel synthesis. J Med Chem 55:9643-53 (2012) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 1
Synonyms:
C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1
Type:
Enzyme
Mol. Mass.:
41180.69
Organism:
Homo sapiens (Human)
Description:
P32246
Residue:
355
Sequence:
METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
  
Inhibitor
Name:
BDBM50399256
Synonyms:
CHEMBL2180543
Type:
Small organic molecule
Emp. Form.:
C25H31ClN2O2
Mol. Mass.:
426.979
SMILES:
CC(C)CC(NC(=O)c1ccccc1C)C(=O)N1CCC(CC1)c1ccc(Cl)cc1
Structure:
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