Reaction Details Report a problem with these data
Target
Peptidyl-prolyl cis-trans isomerase FKBP1A
Ligand
BDBM50288769
Substrate
n/a
Meas. Tech.
ChEBML_66277
Ki
210±n/a nM
Citation
 Tatlock, JH; Kalish, VJ; Parge, H; Knighton, DR; Showalter, RE; Lewis, CT; French, J; Villafranca, J High-affinity FKBP-12 ligands derived from (R)-()-carvone. Synthesis and evaluation of FK506 pyranose ring replacements Bioorg Med Chem Lett 5:2489-2494 (1995)    Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase FKBP1A
Synonyms:
12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B
Type:
Isomerase
Mol. Mass.:
11953.09
Organism:
Homo sapiens (Human)
Description:
P62942
Residue:
108
Sequence:
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
  
Inhibitor
Name:
BDBM50288769
Synonyms:
(S)-1-[2-((1S,2R,5R)-1-Hydroxy-5-isopropyl-2-methyl-cyclohexyl)-2-oxo-acetyl]-piperidine-2-carboxylic acid benzyl ester | CHEMBL316255
Type:
Small organic molecule
Emp. Form.:
C25H35NO5
Mol. Mass.:
429.5491
SMILES:
CC(C)[C@@H]1CC[C@@H](C)[C@@](O)(C1)C(=O)C(=O)N1CCCC[C@H]1C(=O)OCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: