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Found 82 with Last Name = 'parge' and Initial = 'h'
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50403490(CHEMBL312157)
Affinity DataKi:  2.80nMAssay Description:Inhibitory activity of compound against FK506 binding protein 12 was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM34012(3-fluorophenylalanine derivative, 21b)
Affinity DataKi:  6nM ΔG°:  -45.4kJ/molepH: 7.5 T: 2°CAssay Description:The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM34011(3-fluorophenylalanine derivative, 21a)
Affinity DataKi:  8nM ΔG°:  -44.7kJ/molepH: 7.5 T: 2°CAssay Description:The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM34013(3-methylphenylalanine derivative, 22a)
Affinity DataKi:  32nM ΔG°:  -41.3kJ/molepH: 7.5 T: 2°CAssay Description:The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM34014(3-methylphenylalanine derivative, 22b)
Affinity DataKi:  57nM ΔG°:  -40.0kJ/molepH: 7.5 T: 2°CAssay Description:The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n...More data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50403488(CHEMBL81439)
Affinity DataKi:  68nMAssay Description:Inhibitory activity of compound against FK506 binding protein 12 was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM34015(2,3-difluorophenylalanine derivative, 23a)
Affinity DataKi:  78nM ΔG°:  -39.2kJ/molepH: 7.5 T: 2°CAssay Description:The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50403487(CHEMBL82511)
Affinity DataKi:  81nMAssay Description:Inhibitory activity of compound against FK506 binding protein 12 was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM34016(2,3-difluorophenylalanine derivative, 23b)
Affinity DataKi:  89nM ΔG°:  -38.9kJ/molepH: 7.5 T: 2°CAssay Description:The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM34009(naphthalene carboxamide, 18a)
Affinity DataKi:  100nM ΔG°:  -38.6kJ/molepH: 7.5 T: 2°CAssay Description:The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50403489(CHEMBL79747)
Affinity DataKi:  112nMAssay Description:Inhibitory activity of compound against FK506 binding protein 12 was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50408099(CHEMBL57087)
Affinity DataKi:  120nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50408102(CHEMBL55646)
Affinity DataKi:  150nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM34010(benzothiophene carboxamide, 18b)
Affinity DataKi:  179nM ΔG°:  -37.2kJ/molepH: 7.5 T: 2°CAssay Description:The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n...More data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50408104(CHEMBL292238)
Affinity DataKi:  200nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288769((S)-1-[2-((1S,2R,5R)-1-Hydroxy-5-isopropyl-2-methy...)
Affinity DataKi:  210nMAssay Description:Inhibitory activity of compound against FK506 binding protein 12 was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50408110(CHEMBL293284)
Affinity DataKi:  220nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50403486(CHEMBL82427)
Affinity DataKi:  258nMAssay Description:Inhibitory activity of compound against FK506 binding protein 12 was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288762((1S,10R)-14-[2-Oxo-2-(3,4,5-trimethoxy-phenyl)-ace...)
Affinity DataKi:  280nMAssay Description:Compound was evaluated for inhibitory activity against human FKBP-12 rotamaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50408096(CHEMBL301025)
Affinity DataKi:  350nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50408101(CHEMBL293519)
Affinity DataKi:  370nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50408094(CHEMBL59256)
Affinity DataKi:  390nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM34008(amide, 17c)
Affinity DataKi:  525nM ΔG°:  -34.6kJ/molepH: 7.5 T: 2°CAssay Description:The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50408105(CHEMBL294146)
Affinity DataKi:  550nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50408100(CHEMBL57674)
Affinity DataKi:  570nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50408103(CHEMBL293294)
Affinity DataKi:  790nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM34005(pipecolate deriv., 12b)
Affinity DataKi:  800nM ΔG°:  -33.6kJ/molepH: 7.5 T: 2°CAssay Description:The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288763((1S,9R)-5-Benzyloxymethyl-13-[2-oxo-2-(3,4,5-trime...)
Affinity DataKi:  1.20E+3nMAssay Description:Compound was evaluated for inhibitory activity against human FKBP-12 rotamaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288765((1S,9R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-1...)
Affinity DataKi:  1.50E+3nMAssay Description:Compound was evaluated for inhibitory activity against human FKBP-12 rotamaseMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM34003(pipecolate deriv., 11)
Affinity DataKi:  1.70E+3nM ΔG°:  -31.8kJ/molepH: 7.5 T: 2°CAssay Description:The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM34007(urea, 17b)
Affinity DataKi:  4.13E+3nM ΔG°:  -29.7kJ/molepH: 7.5 T: 2°CAssay Description:The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50408107(CHEMBL56789)
Affinity DataKi:  6.50E+3nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50408097(CHEMBL56270)
Affinity DataKi:  7.20E+3nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288764((1S,9R)-13-[2-((1S,2R,5R)-1-Hydroxy-5-isopropyl-2-...)
Affinity DataKi:  8.10E+3nMAssay Description:Compound was evaluated for inhibitory activity against human FKBP-12 rotamaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288768((1R,10S)-14-(3,3-Dimethyl-2-oxo-pentanoyl)-3,8-dio...)
Affinity DataKi:  8.30E+3nMAssay Description:Compound was evaluated for inhibitory activity against human FKBP-12 rotamaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50408109(CHEMBL54055)
Affinity DataKi:  8.40E+3nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM34006(sulfonamide, 17a)
Affinity DataKi:  8.77E+3nM ΔG°:  -27.9kJ/molepH: 7.5 T: 2°CAssay Description:The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM34004(pipecolate deriv., 12a)
Affinity DataKi:  9.46E+3nM ΔG°:  -27.7kJ/molepH: 7.5 T: 2°CAssay Description:The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288767((1R,9S)-13-(3,3-Dimethyl-2-oxo-pentanoyl)-3,7-diox...)
Affinity DataKi:  1.00E+4nMAssay Description:Compound was evaluated for inhibitory activity against human FKBP-12 rotamaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50408106(CHEMBL56927)
Affinity DataKi:  1.40E+4nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50408098(CHEMBL298828)
Affinity DataKi:  2.40E+4nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM34001(pipecolate deriv., 9)
Affinity DataKi: >5.00E+4nM ΔG°: >-23.7kJ/molepH: 7.5 T: 2°CAssay Description:The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288766((1S,9R)-13-{2-[(1S,2R,5R)-1-Hydroxy-5-(2-methoxy-1...)
Affinity DataKi: >5.00E+4nMAssay Description:Compound was evaluated for inhibitory activity against human FKBP-12 rotamaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50408095(CHEMBL292166)
Affinity DataKi:  6.70E+4nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50408108(CHEMBL299276)
Affinity DataKi:  8.30E+4nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288769((S)-1-[2-((1S,2R,5R)-1-Hydroxy-5-isopropyl-2-methy...)
Affinity DataKi:  2.10E+5nMAssay Description:Compound was evaluated for inhibitory activity against human FKBP-12 rotamaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190964(6-(3-chloro-4-methoxyphenethyl)-6-cyclopentyl-4-hy...)
Affinity DataIC50:  38nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190967(6-(3-chloro-4-methoxyphenethyl)-6-cyclopentyl-4-hy...)
Affinity DataIC50:  130nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190951(6-(3-chloro-4-methoxyphenethyl)-6-cyclopentyl-4-hy...)
Affinity DataIC50:  140nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190956(6-(3-chloro-4-methoxyphenethyl)-6-cyclopentyl-4-hy...)
Affinity DataIC50:  280nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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