Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50418015
Substrate
n/a
Meas. Tech.
ChEMBL_728033 (CHEMBL1686904)
EC50
19.95±n/a nM
Citation
 Kiyoi, T; Adam, JM; Clark, JK; Davies, K; Easson, AM; Edwards, D; Feilden, H; Fields, R; Francis, S; Jeremiah, F; McArthur, D; Morrison, AJ; Prosser, A; Ratcliffe, PD; Schulz, J; Wishart, G; Baker, J; Campbell, R; Cottney, JE; Deehan, M; Epemolu, O; Evans, L Discovery of potent and orally bioavailable heterocycle-based cannabinoid CB1 receptor agonists. Bioorg Med Chem Lett 21:1748-53 (2011) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50418015
Synonyms:
CHEMBL1682269
Type:
Small organic molecule
Emp. Form.:
C20H25ClN4O4S2
Mol. Mass.:
485.02
SMILES:
CS(=O)(=O)N(CCO)Cc1nc(ns1)-c1cn(CC2CCOCC2)c2c(Cl)cccc12
Structure:
Search PDB for entries with ligand similarity: