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Target
fMet-Leu-Phe receptor
Ligand
BDBM50419570
Substrate
n/a
Meas. Tech.
ChEMBL_796441 (CHEMBL1937756)
IC50
398±n/a nM
Citation
 Morley, AD; King, S; Roberts, B; Lever, S; Teobald, B; Fisher, A; Cook, T; Parker, B; Wenlock, M; Phillips, C; Grime, K Lead optimisation of pyrazoles as novel FPR1 antagonists. Bioorg Med Chem Lett 22:532-6 (2011) [PubMed]  Article 
Target
Name:
fMet-Leu-Phe receptor
Synonyms:
FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38456.14
Organism:
Homo sapiens (Human)
Description:
gi_4503779
Residue:
350
Sequence:
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
  
Inhibitor
Name:
BDBM50419570
Synonyms:
CHEMBL1934271
Type:
Small organic molecule
Emp. Form.:
C23H36N4O3S
Mol. Mass.:
448.622
SMILES:
CCC(CC)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1 |r|
Structure:
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