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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50420866
Substrate
n/a
Meas. Tech.
ChEMBL_839815 (CHEMBL2089826)
EC50
161±n/a nM
Citation
 Scott, JS; Birch, AM; Brocklehurst, KJ; Broo, A; Brown, HS; Butlin, RJ; Clarke, DS; Davidsson, O; Ertan, A; Goldberg, K; Groombridge, SD; Hudson, JA; Laber, D; Leach, AG; Macfaul, PA; McKerrecher, D; Pickup, A; Schofield, P; Svensson, PH; Sörme, P; Teague, J Use of small-molecule crystal structures to address solubility in a novel series of G protein coupled receptor 119 agonists: optimization of a lead and in vivo evaluation. J Med Chem 55:5361-79 (2012) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50420866
Synonyms:
CHEMBL2086657
Type:
Small organic molecule
Emp. Form.:
C20H27N5O5S
Mol. Mass.:
449.524
SMILES:
CC(C)(C)OC(=O)N1CCN(CC1)c1ncc(OCc2ccc(cc2)S(C)(=O)=O)nn1
Structure:
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