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Target
Cathepsin B-like cysteine protease
Ligand
BDBM50421237
Substrate
n/a
Meas. Tech.
ChEMBL_840092 (CHEMBL2090696)
IC50
59000±n/a nM
Citation
 Lavrado, J; Mackey, Z; Hansell, E; McKerrow, JH; Paulo, A; Moreira, R Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives. Bioorg Med Chem Lett 22:6256-60 (2012) [PubMed]  Article 
Target
Name:
Cathepsin B-like cysteine protease
Synonyms:
CPC | Cathepsin B-Like Cysteine Protease (TbcatB) | Cysteine peptidase C | TbcatB
Type:
Enzyme
Mol. Mass.:
37220.37
Organism:
Trypanosoma brucei
Description:
Enzyme was expressed in yeast Pichia pastoris.
Residue:
340
Sequence:
MHLMRACITFCIASTAVVAVNAALVAEDAPVLSKAFVDRVNRLNRGIWKAKYDGVMQNITLREAKRLNGVIKKNNNASILPKRRFTEEEARAPLPSSFDSAEAWPNCPTIPQIADQSACGSCWAVAAASAMSDRFCTMGGVQDVHISAGDLLACCSDCGDGCNGGDPDRAWAYFSSTGLVSDYCQPYPFPHCSHHSKSKNGYPPCSQFNFDTPKCNYTCDDPTIPVVNYRSWTSYALQGEDDYMRELFFRGPFEVAFDVYEDFIAYNSGVYHHVSGQYLGGHAVRLVGWGTSNGVPYWKIANSWNTEWGMDGYFLIRRGSSECGIEDGGSAGIPLAPNTA
  
Inhibitor
Name:
BDBM50421237
Synonyms:
CHEMBL1290599
Type:
Small organic molecule
Emp. Form.:
C27H29N4O
Mol. Mass.:
425.5448
SMILES:
CCN(CC)Cc1ccc(Nc2c3[nH+]c4ccccc4c3n(C)c3ccccc23)cc1O
Structure:
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