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Target
Cathepsin B-like cysteine protease
Ligand
BDBM50264499
Substrate
n/a
Meas. Tech.
ChEMBL_840092 (CHEMBL2090696)
IC50
31000±n/a nM
Citation
 Lavrado, J; Mackey, Z; Hansell, E; McKerrow, JH; Paulo, A; Moreira, R Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives. Bioorg Med Chem Lett 22:6256-60 (2012) [PubMed]  Article 
Target
Name:
Cathepsin B-like cysteine protease
Synonyms:
CPC | Cathepsin B-Like Cysteine Protease (TbcatB) | Cysteine peptidase C | TbcatB
Type:
Enzyme
Mol. Mass.:
37220.37
Organism:
Trypanosoma brucei
Description:
Enzyme was expressed in yeast Pichia pastoris.
Residue:
340
Sequence:
MHLMRACITFCIASTAVVAVNAALVAEDAPVLSKAFVDRVNRLNRGIWKAKYDGVMQNITLREAKRLNGVIKKNNNASILPKRRFTEEEARAPLPSSFDSAEAWPNCPTIPQIADQSACGSCWAVAAASAMSDRFCTMGGVQDVHISAGDLLACCSDCGDGCNGGDPDRAWAYFSSTGLVSDYCQPYPFPHCSHHSKSKNGYPPCSQFNFDTPKCNYTCDDPTIPVVNYRSWTSYALQGEDDYMRELFFRGPFEVAFDVYEDFIAYNSGVYHHVSGQYLGGHAVRLVGWGTSNGVPYWKIANSWNTEWGMDGYFLIRRGSSECGIEDGGSAGIPLAPNTA
  
Inhibitor
Name:
BDBM50264499
Synonyms:
CHEMBL253508 | CHEMBL507633 | N-(5-N-Methyl-10H-indolo[3,2-b]quinolin-5-ium)-N,N-dimethylpropane-1,3-diamine Iodide
Type:
Small organic molecule
Emp. Form.:
C21H25N4
Mol. Mass.:
333.4495
SMILES:
CN(C)CCCNc1c2[nH+]c3ccccc3c2n(C)c2ccccc12
Structure:
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