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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50433853
Substrate
n/a
Meas. Tech.
ChEMBL_959598 (CHEMBL2382543)
IC50
9.0±n/a nM
Citation
 Scott, JS; Brocklehurst, KJ; Brown, HS; Clarke, DS; Coe, H; Groombridge, SD; Laber, D; MacFaul, PA; McKerrecher, D; Schofield, P Conformational restriction in a series of GPR119 agonists: differences in pharmacology between mouse and human. Bioorg Med Chem Lett 23:3175-9 (2013) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50433853
Synonyms:
CHEMBL2382413
Type:
Small organic molecule
Emp. Form.:
C22H20F4N6O3
Mol. Mass.:
492.4262
SMILES:
FC1(F)CC(OC(=O)N2C3CCC2CN(C3)c2ncc(OCc3ccncc3C#N)cn2)C1(F)F
Structure:
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