Reaction Details
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Fatty-acid amide hydrolase 1 [30-579]
Ligand
BDBM50434315
Substrate
n/a
Meas. Tech.
ChEMBL_960984 (CHEMBL2388900)
IC50
1.4±n/a nM
Citation
Liu, P; Hamill, TG; Chioda, M; Chobanian, H; Fung, S; Guo, Y; Chang, L; Bakshi, R; Hong, Q; Dellureficio, J; Lin, LS; Abbadie, C; Alexander, J; Jin, H; Mandala, S; Shiao, LL; Li, W; Sanabria, S; Williams, D; Zeng, Z; Hajdu, R; Jochnowitz, N; Rosenbach, M; Karanam, B; Madeira, M; Salituro, G; Powell, J; Xu, L; Terebetski, JL; Leone, JF; Miller, P; Cook, J; Holahan, M; Joshi, A; O'Malley, S; Purcell, M; Posavec, D; Chen, TB; Riffel, K; Williams, M; Hargreaves, R; Sullivan, KA; Nargund, RP; DeVita, RJ Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase. ACS Med Chem Lett 4:509-13 (2013) [PubMed] Article More Info.:
Target
Name:
Fatty-acid amide hydrolase 1 [30-579]
Synonyms:
Anandamide amidohydrolase 1 | FAAH1_RAT | Faah | Faah1 | Fatty Acid Amide Hydrolase | Fatty Acid Amide Hydrolic, FAAH | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Fatty-acid amide hydrolase 1 (FAAH) | Fatty-acid amide hydrolase 1 (aa 30-579) | Oleamide hydrolase 1
Type:
Single-pass membrane protein; homodimer
Mol. Mass.:
60474.00
Organism:
Rattus norvegicus (rat)
Description:
P97612 (aa 30-579)
Residue:
550
Sequence:
RWTGRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTPQKQPS
Inhibitor
Name:
BDBM50434315
Synonyms:
CHEMBL2386569
Type:
Small organic molecule
Emp. Form.:
C22H21ClFN3OS
Mol. Mass.:
429.938
SMILES:
Cn1cnc(c1Sc1ccc(Cl)cc1)-c1ccc(cc1)[C@H]1C[C@@H]1C(=O)NCCF |r|
Structure:
