Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM50437756
Substrate
n/a
Meas. Tech.
ChEMBL_973380 (CHEMBL2410086)
IC50
330±n/a nM
Citation
 Kwak, HJ; Pyun, YM; Kim, JY; Pagire, HS; Kim, KY; Kim, KR; Rhee, SD; Jung, WH; Song, JS; Bae, MA; Lee, DH; Ahn, JH Synthesis and biological evaluation of aminobenzimidazole derivatives with a phenylcyclohexyl acetic acid group as anti-obesity and anti-diabetic agents. Bioorg Med Chem Lett 23:4713-8 (2013) [PubMed]  Article 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:
Protein
Mol. Mass.:
55297.82
Organism:
Homo sapiens (Human)
Description:
O75907
Residue:
488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
  
Inhibitor
Name:
BDBM50437756
Synonyms:
CHEMBL2409560
Type:
Small organic molecule
Emp. Form.:
C34H31N3O3
Mol. Mass.:
529.6282
SMILES:
OC(=O)CC1CCC(CC1)c1ccc(cc1)-c1nc2ccc(NC(=O)c3ccc(cc3)-c3ccccc3)cc2[nH]1 |(22.7,-17.53,;21.16,-17.54,;20.38,-16.21,;20.4,-18.88,;18.86,-18.89,;18.1,-20.23,;16.57,-20.25,;15.78,-18.92,;16.53,-17.58,;18.08,-17.57,;14.25,-18.95,;13.49,-20.29,;11.95,-20.3,;11.17,-18.98,;11.92,-17.64,;13.45,-17.62,;9.63,-19,;8.74,-20.25,;7.27,-19.79,;5.93,-20.57,;4.6,-19.81,;4.6,-18.27,;3.26,-17.51,;1.93,-18.28,;1.94,-19.82,;.59,-17.52,;.6,-15.98,;-.75,-15.21,;-2.08,-15.99,;-2.08,-17.54,;-.74,-18.29,;-3.41,-15.23,;-3.42,-13.69,;-4.76,-12.93,;-6.09,-13.7,;-6.07,-15.25,;-4.73,-16.01,;5.92,-17.49,;7.26,-18.25,;8.72,-17.76,)|
Structure:
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