Reaction Details Report a problem with these data
Target
Alkaline phosphatase, placental type
Ligand
BDBM76212
Substrate
n/a
Meas. Tech.
ChEMBL_1288274 (CHEMBL3117348)
IC50
>100000±n/a nM
Citation
Ardecky, RJ; Bobkova, EV; Kiffer-Moreira, T; Brown, B; Ganji, S; Zou, J; Pass, I; Narisawa, S; Iano, FG; Rosenstein, C; Cheltsov, A; Rascon, J; Hedrick, M; Gasior, C; Forster, A; Shi, S; Dahl, R; Vasile, S; Su, Y; Sergienko, E; Chung, TD; Kaunitz, J; Hoylaerts, MF; Pinkerton, AB; Millán, JL Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes. Bioorg Med Chem Lett 24:1000-4 (2014) [PubMed] Article
More Info.:
Target
Name:
Alkaline phosphatase, placental type
Synonyms:
ALPP | Alkaline phosphatase placental type | PLAP | PPB1_HUMAN
Type:
PROTEIN
Mol. Mass.:
57950.65
Organism:
Human
Description:
ChEMBL_1506090
Residue:
535
Sequence:
MLGPCMLLLLLLLGLRLQLSLGIIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAGTTDAAHPGRSVVPALLPLLAGTLLLLETATAP
Inhibitor
Name:
BDBM76212
Synonyms:
3-[(2-keto-3H-1,3-benzoxazol-6-yl)sulfonylamino]-N-o-anisyl-propionamide | CHEMBL1470091 | MLS001096065 | N-[(2-methoxyphenyl)methyl]-3-[(2-oxidanylidene-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide | N-[(2-methoxyphenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide | SMR000631046 | cid_24790972
Type:
Small organic molecule
Emp. Form.:
C18H19N3O6S
Mol. Mass.:
405.425
SMILES:
COc1ccccc1CNC(=O)CCNS(=O)(=O)c1ccc2[nH]c(=O)oc2c1