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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM2583
Substrate
n/a
Meas. Tech.
ChEMBL_326168 (CHEMBL864489)
Kd
27±n/a nM
Citation
 Bullock, AN; Debreczeni, JE; Fedorov, OY; Nelson, A; Marsden, BD; Knapp, S Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase. J Med Chem 48:7604-14 (2005) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM2583
Synonyms:
3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione | 3,4-bis(1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione | BIM-4 | Bisindolyl deriv. 3 | Bisindolylmaleimide deriv. 5 | CHEMBL266487 | bis-indolylmaleimide deriv. 8a
Type:
Small organic molecule
Emp. Form.:
C20H13N3O2
Mol. Mass.:
327.3361
SMILES:
O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 |c:5|
Structure:
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