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Target
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI [9-251]
Ligand
BDBM97445
Substrate
n/a
Meas. Tech.
ChEMBL_1431241 (CHEMBL3385666)
Ki
0.010000±n/a nM
Citation
 Wang, H; Lu, Y; Liu, L; Kim, SW; Hooker, JM; Fowler, JS; Tonge, PJ Radiosynthesis and biological evaluation of a novel enoyl-ACP reductase inhibitor for Staphylococcus aureus. Eur J Med Chem 88:66-73 (2014) [PubMed]  Article 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI [9-251]
Synonyms:
Enoyl-ACP reductase | FABI_STAAR | fabI
Type:
PROTEIN
Mol. Mass.:
26446.66
Organism:
Staphylococcus aureus
Description:
ChEMBL_1455655
Residue:
243
Sequence:
YVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSG
  
Inhibitor
Name:
BDBM97445
Synonyms:
PT119
Type:
Small molecule
Emp. Form.:
C19H21NO2
Mol. Mass.:
295.3755
SMILES:
CCCCCCc1ccc(Oc2ccccc2C#N)c(O)c1
Structure:
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