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Found 1247 with Last Name = 'kim' and Initial = 'sw'
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI [9-251](Staphylococcus aureus)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM97445(PT119)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of Staphylococcus aureus enoyl ACP reductaseMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50069294((S)-3-[4-(carbohydrazonamidol)-phenyl]-N-cyclopent...)
Affinity DataKi:  0.380nMAssay Description:Binding affinity towards human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50426499(CHEMBL2323581)
Affinity DataKi:  0.540nMAssay Description:Displacement of [125I](+/-)DOI from human 5-HT2B receptor trasfected in CHO cell membrane after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50426500(CHEMBL2323580)
Affinity DataKi:  0.970nMAssay Description:Displacement of [125I](+/-)DOI from human 5-HT2B receptor trasfected in CHO cell membrane after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50426498(1,6-Dimethylcabergoline | CHEMBL2323579)
Affinity DataKi:  1nMAssay Description:Displacement of [125I](+/-)DOI from human 5-HT2B receptor trasfected in CHO cell membrane after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50426497(CABERGOLINE | Dostinex | FCE-21336)
Affinity DataKi:  1.40nMAssay Description:Displacement of [125I](+/-)DOI from human 5-HT2B receptor trasfected in CHO cell membrane after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50070181(1-(3-Dimethylamino-propyl)-3-ethyl-1-((6aR,9R,10aR...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [125I](+/-)DOI from human 5-HT2B receptor trasfected in CHO cell membrane after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50071729(CHEMBL313826 | Naphthalene-2-sulfonic acid [(S)-1-...)
Affinity DataKi:  3.10nMAssay Description:Binding affinity towards human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50071723((S)-3-(4-Aminomethyl-phenyl)-N-cyclopentyl-N-methy...)
Affinity DataKi:  3.30nMAssay Description:Binding affinity towards human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50071725((S)-3-(4-Aminomethyl-phenyl)-2-(anthracene-2-sulfo...)
Affinity DataKi:  5.70nMAssay Description:Binding affinity towards human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50071722((S)-3-(4-Aminomethyl-phenyl)-N-cyclopentyl-2-(6-me...)
Affinity DataKi:  6.60nMAssay Description:Binding affinity towards human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50070783((S)-3-(4-Carbamimidoyl-phenyl)-N-cyclopentyl-N-met...)
Affinity DataKi:  6.80nMAssay Description:Binding affinity towards human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50426501(CHEMBL2323578)
Affinity DataKi:  7.10nMAssay Description:Displacement of [125I](+/-)DOI from human 5-HT2B receptor trasfected in CHO cell membrane after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50401014(CHEMBL2206307)
Affinity DataKi:  8nMAssay Description:Binding affinity to DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50069055((S)-3-(4-Aminomethyl-phenyl)-N-cyclopentyl-N-methy...)
Affinity DataKi:  9.60nMAssay Description:Binding affinity towards human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50069055((S)-3-(4-Aminomethyl-phenyl)-N-cyclopentyl-N-methy...)
Affinity DataKi:  10nMAssay Description:Inhibition constant was evaluated for inhibitory activity against the blood coagulant thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50071726((S)-3-(4-Aminomethyl-phenyl)-N-cyclopentyl-N-methy...)
Affinity DataKi:  10nMAssay Description:Binding affinity towards human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50071724((S)-3-(4-Aminomethyl-phenyl)-N-cyclopentyl-2-(5-di...)
Affinity DataKi:  11nMAssay Description:Binding affinity towards human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50069053((S)-3-(4-Aminomethyl-phenyl)-N-cyclopentyl-N-methy...)
Affinity DataKi:  18nMAssay Description:Binding affinity towards human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50071721((S)-3-(4-Aminomethyl-phenyl)-2-(4-cyclohexyl-benze...)
Affinity DataKi:  20nMAssay Description:Binding affinity towards human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50069053((S)-3-(4-Aminomethyl-phenyl)-N-cyclopentyl-N-methy...)
Affinity DataKi:  50nMAssay Description:Inhibition constant was evaluated for inhibitory activity against the blood coagulant thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50071728((S)-3-(4-Aminomethyl-phenyl)-2-(biphenyl-4-sulfony...)
Affinity DataKi:  61nMAssay Description:Binding affinity towards human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50071727((S)-3-(4-Aminomethyl-phenyl)-N-cyclopentyl-N-methy...)
Affinity DataKi:  107nMAssay Description:Binding affinity towards human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50069052(CHEMBL164661 | Naphthalene-2-sulfonic acid [(S)-1-...)
Affinity DataKi:  200nMAssay Description:Inhibition constant was evaluated for inhibitory activity against the blood coagulant thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50069051((S)-3-(4-Aminomethyl-phenyl)-N-isopropyl-N-methyl-...)
Affinity DataKi:  600nMAssay Description:Inhibition constant was evaluated for inhibitory activity against the blood coagulant thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50069057((S)-3-(4-Aminomethyl-phenyl)-N,N-dimethyl-2-(napht...)
Affinity DataKi:  3.06E+3nMAssay Description:Inhibition constant was evaluated for inhibitory activity against the blood coagulant thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50071725((S)-3-(4-Aminomethyl-phenyl)-2-(anthracene-2-sulfo...)
Affinity DataKi:  3.30E+3nMAssay Description:Binding affinity of the compound towards bovine trypsin was evaluated in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50071721((S)-3-(4-Aminomethyl-phenyl)-2-(4-cyclohexyl-benze...)
Affinity DataKi:  4.80E+3nMAssay Description:Binding affinity of the compound towards bovine trypsin was evaluated in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50071723((S)-3-(4-Aminomethyl-phenyl)-N-cyclopentyl-N-methy...)
Affinity DataKi:  6.30E+3nMAssay Description:Binding affinity of the compound towards bovine trypsin was evaluated in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50069055((S)-3-(4-Aminomethyl-phenyl)-N-cyclopentyl-N-methy...)
Affinity DataKi:  9.04E+3nMAssay Description:Binding affinity of the compound towards bovine trypsin was evaluated in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50071726((S)-3-(4-Aminomethyl-phenyl)-N-cyclopentyl-N-methy...)
Affinity DataKi:  9.80E+3nMAssay Description:Binding affinity of the compound towards bovine trypsin was evaluated in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50069053((S)-3-(4-Aminomethyl-phenyl)-N-cyclopentyl-N-methy...)
Affinity DataKi:  1.36E+4nMAssay Description:Binding affinity of the compound towards bovine trypsin was evaluated in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50071722((S)-3-(4-Aminomethyl-phenyl)-N-cyclopentyl-2-(6-me...)
Affinity DataKi:  1.42E+4nMAssay Description:Binding affinity of the compound towards bovine trypsin was evaluated in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50069056(CHEMBL350751 | Naphthalene-2-sulfonic acid [(S)-1-...)
Affinity DataKi:  1.56E+4nMAssay Description:Inhibition constant was evaluated for inhibitory activity against the blood coagulant thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50071724((S)-3-(4-Aminomethyl-phenyl)-N-cyclopentyl-2-(5-di...)
Affinity DataKi:  1.71E+4nMAssay Description:Binding affinity of the compound towards bovine trypsin was evaluated in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50069054((S)-3-(4-Aminomethyl-phenyl)-N-isopropyl-2-(naphth...)
Affinity DataKi:  3.17E+4nMAssay Description:Inhibition constant was evaluated for inhibitory activity against the blood coagulant thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50069050((S)-3-(4-Aminomethyl-phenyl)-N-benzyl-2-(naphthale...)
Affinity DataKi:  9.72E+4nMAssay Description:Inhibition constant was evaluated for inhibitory activity against the blood coagulant thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Genosco

US Patent
LigandPNGBDBM138211(US8871778, 190)
Affinity DataIC50:  0.100nMT: 2°CAssay Description:Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Genosco

US Patent
LigandPNGBDBM138212(US8871778, 198)
Affinity DataIC50:  0.100nMT: 2°CAssay Description:Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Genosco

US Patent
LigandPNGBDBM138217(US8871778, 251)
Affinity DataIC50:  0.600nMT: 2°CAssay Description:Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50304788(CHEMBL594160 | methyl 4-(3-chloro-4-methoxybenzyla...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of bovine platelet PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Genosco

US Patent
LigandPNGBDBM138204(US8871778, 161)
Affinity DataIC50:  0.700nMT: 2°CAssay Description:Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Genosco

US Patent
LigandPNGBDBM138219(US8871778, 255)
Affinity DataIC50:  0.700nMT: 2°CAssay Description:Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Genosco

US Patent
LigandPNGBDBM138201(US8871778, 144)
Affinity DataIC50:  0.700nMT: 2°CAssay Description:Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Genosco

US Patent
LigandPNGBDBM138210(US8871778, 189)
Affinity DataIC50:  1nMT: 2°CAssay Description:Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50246252(CHEMBL521075 | N-(4-(3-chloro-4-methoxybenzylamino...)
Affinity DataIC50:  1nMAssay Description:Inhibition of bovine platelet PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Genosco

US Patent
LigandPNGBDBM138200(US8871778, 141)
Affinity DataIC50:  1nMT: 2°CAssay Description:Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50304789(CHEMBL604271 | N-(4-(3-chloro-4-methoxybenzylamino...)
Affinity DataIC50:  1nMAssay Description:Inhibition of bovine platelet PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Genosco

US Patent
LigandPNGBDBM138207(US8871778, 176)
Affinity DataIC50:  1nMT: 2°CAssay Description:Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50304792(CHEMBL595104 | N-(4-(3-chloro-4-methoxybenzylamino...)
Affinity DataIC50:  1nMAssay Description:Inhibition of bovine platelet PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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