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Target
Nuclear receptor ROR-gamma
Ligand
BDBM50035910
Substrate
n/a
Meas. Tech.
ChEMBL_1442781 (CHEMBL3375303)
EC50
56±n/a nM
Citation
 van Niel, MB; Fauber, BP; Cartwright, M; Gaines, S; Killen, JC; René, O; Ward, SI; de Leon Boenig, G; Deng, Y; Eidenschenk, C; Everett, C; Gancia, E; Ganguli, A; Gobbi, A; Hawkins, J; Johnson, AR; Kiefer, JR; La, H; Lockey, P; Norman, M; Ouyang, W; Qin, A; Wakes, N; Waszkowycz, B; Wong, H A reversed sulfonamide series of selective RORc inverse agonists. Bioorg Med Chem Lett 24:5769-76 (2014) [PubMed]  Article 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM50035910
Synonyms:
CHEMBL3361053
Type:
Small organic molecule
Emp. Form.:
C25H31F3N2O5S2
Mol. Mass.:
560.649
SMILES:
CC(C)CN(Cc1ccccc1C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(=O)C1CCN(CC1)S(C)(=O)=O
Structure:
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