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Target
Sodium-dependent proline transporter
Ligand
BDBM50052729
Substrate
n/a
Meas. Tech.
ChEMBL_1456629 (CHEMBL3370229)
IC50
27±n/a nM
Citation
 Zipp, GG; Barbosa, J; Green, MA; Terranova, KM; Fink, C; Yu, XC; Nouraldeen, A; Wilson, A; Savelieva, K; Lanthorn, TH; David Kimball, S Novel inhibitors of the high-affinity L-proline transporter as potential therapeutic agents for the treatment of cognitive disorders. Bioorg Med Chem Lett 24:3886-90 (2014) [PubMed]  Article 
Target
Name:
Sodium-dependent proline transporter
Synonyms:
PROT | SC6A7_HUMAN | SLC6A7 | Sodium-dependent proline transporter | Solute carrier family 6 member 7
Type:
PROTEIN
Mol. Mass.:
70910.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109456
Residue:
636
Sequence:
MKKLQGAHLRKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQSPKPLMVHMRKYGGITSFENTAIEVDREIAEEEESMM
  
Inhibitor
Name:
BDBM50052729
Synonyms:
CHEMBL3318585
Type:
Small organic molecule
Emp. Form.:
C23H21ClN4O
Mol. Mass.:
404.892
SMILES:
Clc1cccc(c1)-c1ccc(cc1)C(=O)N1CC2CCC(C1)N2c1ncccn1 |TLB:13:15:22:18.19|
Structure:
Search PDB for entries with ligand similarity: