Reaction Details Report a problem with these data
Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM50097389
Substrate
n/a
Meas. Tech.
ChEMBL_1501664 (CHEMBL3587483)
Ki
765±n/a nM
Citation
 Letavic, MA; Bonaventure, P; Carruthers, NI; Dugovic, C; Koudriakova, T; Lord, B; Lovenberg, TW; Ly, KS; Mani, NS; Nepomuceno, D; Pippel, DJ; Rizzolio, M; Shelton, JE; Shah, CR; Shireman, BT; Young, LK; Yun, S Novel Octahydropyrrolo[3,4-c]pyrroles Are Selective Orexin-2 Antagonists: SAR Leading to a Clinical Candidate. J Med Chem 58:5620-36 (2015) [PubMed]  Article 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM50097389
Synonyms:
CHEMBL3586421
Type:
Small organic molecule
Emp. Form.:
C29H26N4O
Mol. Mass.:
446.5429
SMILES:
[H][C@@]12CN(C[C@]1([H])CN(C2)c1nccc(n1)-c1ccccc1)C(=O)c1ccccc1-c1ccccc1 |r|
Structure:
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