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Target
Cyclin-C
Ligand
BDBM50105152
Substrate
n/a
Meas. Tech.
ChEMBL_1577630 (CHEMBL3807238)
IC50
75±n/a nM
Citation
 Koehler, MF; Bergeron, P; Blackwood, EM; Bowman, K; Clark, KR; Firestein, R; Kiefer, JR; Maskos, K; McCleland, ML; Orren, L; Salphati, L; Schmidt, S; Schneider, EV; Wu, J; Beresini, MH Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells. ACS Med Chem Lett 7:223-8 (2016) [PubMed]  Article 
Target
Name:
Cyclin-C
Synonyms:
CCNC | CCNC_HUMAN | Cyclin C | SRB11 homolog | hSRB11
Type:
PROTEIN
Mol. Mass.:
33244.88
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107900
Residue:
283
Sequence:
MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
  
Inhibitor
Name:
BDBM50105152
Synonyms:
4-(4-Chloro-phenoxy)-thieno[2,3-c]pyridine-2-carboxylic acid dimethylamide | CHEMBL324133
Type:
Small organic molecule
Emp. Form.:
C16H13ClN2O2S
Mol. Mass.:
332.805
SMILES:
CN(C)C(=O)c1cc2c(Oc3ccc(Cl)cc3)cncc2s1
Structure:
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