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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50176871
Substrate
n/a
Meas. Tech.
ChEMBL_1581631 (CHEMBL3817394)
Ki
21000±n/a nM
Citation
 Gowthaman, R; Miller, SA; Rogers, S; Khowsathit, J; Lan, L; Bai, N; Johnson, DK; Liu, C; Xu, L; Anbanandam, A; Aubé, J; Roy, A; Karanicolas, J DARC: Mapping Surface Topography by Ray-Casting for Effective Virtual Screening at Protein Interaction Sites. J Med Chem 59:4152-70 (2016) [PubMed]  Article 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50176871
Synonyms:
CHEMBL1456767
Type:
Small organic molecule
Emp. Form.:
C18H18O6
Mol. Mass.:
330.3319
SMILES:
COc1cc(O)c(C(=O)\C=C\c2ccc(O)c(OC)c2)c(OC)c1
Structure:
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