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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50232624
Substrate
n/a
Meas. Tech.
ChEMBL_1648274 (CHEMBL3997330)
EC50
1.6±n/a nM
Citation
 Zhu, C; Wang, L; Zhu, Y; Guo, ZZ; Liu, P; Hu, Z; Szewczyk, JW; Kang, L; Chicchi, G; Ehrhardt, A; Woods, A; Seo, T; Woods, M; van Heek, M; Dingley, KH; Pang, J; Salituro, GM; Powell, J; Terebetski, JL; Hornak, V; Campeau, LC; Orr, RK; Ujjainwalla, F; Miller, M; Stamford, A; Wood, HB; Kowalski, T; Nargund, RP; Edmondson, SD Discovery of phenyl acetamides as potent and selective GPR119 agonists. Bioorg Med Chem Lett 27:1124-1128 (2017) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
GP119_MOUSE | Gpr119
Type:
PROTEIN
Mol. Mass.:
37009.07
Organism:
Mus musculus
Description:
ChEMBL_1506420
Residue:
335
Sequence:
MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGACIAGLWLVSYLIGFLPLGVSIFQQTTYHGPCSFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQQIRKMEHAGAMAGAYRPPRSVNDFKAVRTIAVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLYHMALGVKKFFTSILLLLPARNRGPERTRESAYHIVTISHPELDG
  
Inhibitor
Name:
BDBM50232624
Synonyms:
CHEMBL4099186
Type:
Small organic molecule
Emp. Form.:
C25H30ClFN4O2
Mol. Mass.:
472.983
SMILES:
Fc1cc(CC(=O)N2CCC2)ccc1OCC[C@@H]1C[C@@H]1C1CCN(CC1)c1ncc(Cl)cn1 |r|
Structure:
Search PDB for entries with ligand similarity: