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Target
Beta-2 adrenergic receptor
Ligand
BDBM50235078
Substrate
n/a
Meas. Tech.
ChEMBL_1654659 (CHEMBL4004025)
IC50
>20000±n/a nM
Citation
 Harper, BH; Wang, L; Zhu, C; Kar, NF; Li, B; Moyes, CR; Goble, SD; Costa, M; Dingley, K; Di Salvo, J; Ha, SN; Hurley, A; Li, X; Miller, RR; Nagabukuro, H; Salituro, GM; Smith, S; Struthers, M; Hale, JJ; Edmondson, SD; Berger, R Investigation of piperazine benzamides as humanß Bioorg Med Chem Lett 27:1094-1098 (2017) [PubMed]  Article 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Homo sapiens (Human)
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
  
Inhibitor
Name:
BDBM50235078
Synonyms:
CHEMBL4092912
Type:
Small organic molecule
Emp. Form.:
C29H37N7O2
Mol. Mass.:
515.6498
SMILES:
[H][C@@]1(CC[C@@H](Cc2ccc(cc2)C(=O)N2CCN(Cc3nnn(CC4CC4)n3)CC2)N1)[C@H](O)c1ccccc1 |r|
Structure:
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