Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50363564
Substrate
n/a
Meas. Tech.
ChEMBL_1657492 (CHEMBL4006962)
IC50
599±n/a nM
Citation
Sainas, S; Pippione, AC; Giorgis, M; Lupino, E; Goyal, P; Ramondetti, C; Buccinną, B; Piccinini, M; Braga, RC; Andrade, CH; Andersson, M; Moritzer, AC; Friemann, R; Mensa, S; Al-Kadaraghi, S; Boschi, D; Lolli, ML Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds. Eur J Med Chem 129:287-302 (2017) [PubMed] Article
More Info.:
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Homo sapiens (Human)
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND