Reaction Details Report a problem with these data
Target
Glycogen synthase kinase-3 beta
Ligand
BDBM97719
Substrate
n/a
Meas. Tech.
Biochemical Assay
Temperature
303.15±n/a K
IC50
30±0.0 nM
Comments
extracted
Citation
 Siegel, S; Wilmen, A; Röhrig, S; Svenstrup, N; Gnoth, MJ; Heitmeier, S; Rester, U; Tersteegen, A; Gerisch, M Imidazo-, pyrazolopyrazines and imidazotriazines and their use US Patent  US8476267 Publication Date 7/2/2013 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM97719
Synonyms:
US8476267, 5
Type:
Small organic molecule
Emp. Form.:
C28H30Cl2N10O
Mol. Mass.:
593.51
SMILES:
CN1CCN(CCNC(=O)c2cc3c(NCCNc4ccc(cn4)C#N)nc(cn3n2)-c2ccc(Cl)cc2Cl)CC1
Structure:
Search PDB for entries with ligand similarity: