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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM97720
Substrate
n/a
Meas. Tech.
Biochemical Assay
Temperature
303.15±n/a K
IC50
310±0.0 nM
Comments
extracted
Citation
 Siegel, S; Wilmen, A; Röhrig, S; Svenstrup, N; Gnoth, MJ; Heitmeier, S; Rester, U; Tersteegen, A; Gerisch, M Imidazo-, pyrazolopyrazines and imidazotriazines and their use US Patent  US8476267 Publication Date 7/2/2013 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM97720
Synonyms:
US8476267, 9
Type:
Small organic molecule
Emp. Form.:
C21H20N8
Mol. Mass.:
384.4371
SMILES:
Cc1nc(C)n2nc(nc(NCCNc3ccc(cn3)C#N)c12)-c1ccccc1
Structure:
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