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Target
Sentrin-specific protease 2
Ligand
BDBM103826
Substrate
SUMO1
Meas. Tech.
SUMO Cleavage Assay
pH
7.4±0
IC50
1.42e+3± 3.0e+3 nM
Citation
 Madu, IG; Namanja, AT; Su, Y; Wong, S; Li, YJ; Chen, Y Identification and Characterization of a New Chemotype of Noncovalent SENP Inhibitors. ACS Chem Biol 8:1435-41 (2013) [PubMed]  Article 
Target
Name:
Sentrin-specific protease 2
Synonyms:
KIAA1331 | SENP2 | SENP2_HUMAN | Sentrin-specific protease 2 (SENP2)
Type:
Protein
Mol. Mass.:
67890.62
Organism:
Homo sapiens (Human)
Description:
Q9HC62
Residue:
589
Sequence:
MYRWLVRILGTIFRFCDRSVPPARALLKRRRSDSTLFSTVDTDEIPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVTSACNGTRNVAPSGEVFSNSSSCELTGSGSWNNMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKPQEQAVTEMISEESGKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPVTSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRGPLCSLRSEKRCSKGKITDTETMVGIRFENESRRGYQLEPDLSEEVSARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDRRTDDLLELTEDMEKEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEVINFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKGVNLFEQEIILVPIHRKVHWSLVVIDLRKKCLKYLDSMGQKGHRICEILLQYLQDESKTKRNSDLNLLEWTHHSMKPHEIPQQLNGSDCGMFTCKYADYISRDKPITFTQHQMPLFRKKMVWEILHQQLL
  
Inhibitor
Name:
BDBM103826
Synonyms:
SPI-01 | US11041859, Code SPI-01 | US9791447, Compound SPI-01
Type:
Small organic molecule
Emp. Form.:
C34H26N6O6S2
Mol. Mass.:
678.737
SMILES:
Nc1ccc2ccccc2c1\N=N\c1ccc(\C=C\c2ccc(cc2S(O)(=O)=O)\N=N\c2c(N)ccc3ccccc23)c(c1)S(O)(=O)=O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Small ubiquitin-related modifier 1
Synonyms:
SMT3C | SMT3H3 | SUMO1 | SUMO1_HUMAN | Small ubiquitin-related modifier 1 | UBL1
Type:
Protein
Mol. Mass.:
11553.84
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
101
Sequence:
MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV