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Target
Sentrin-specific protease 1
Ligand
BDBM103831
Substrate
SUMO2
Meas. Tech.
SUMO Cleavage Assay
pH
7.4±0
IC50
4.32e+4± 2.2e+3 nM
Citation
 Madu, IG; Namanja, AT; Su, Y; Wong, S; Li, YJ; Chen, Y Identification and Characterization of a New Chemotype of Noncovalent SENP Inhibitors. ACS Chem Biol 8:1435-41 (2013) [PubMed]  Article 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM103831
Synonyms:
SPI-06
Type:
Small organic molecule
Emp. Form.:
C17H15N3O3S
Mol. Mass.:
341.384
SMILES:
Cc1ccccc1\N=N\c1cc(c2ccccc2c1N)S(O)(=O)=O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Small ubiquitin-related modifier 2
Synonyms:
SMT3B | SMT3H2 | SUMO2 | SUMO2_HUMAN | Small ubiquitin-related modifier 2
Type:
Protein
Mol. Mass.:
10869.09
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
95
Sequence:
MADEKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVY