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Target
Complement factor D
Ligand
BDBM111076
Substrate
n/a
Meas. Tech.
Human Factor D Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
<1000±n/a nM
Comments
extracted
Citation
 Wiles, JA; Wang, Q; Gadhachanda, VR; Pais, G; Hashimoto, A; Chen, D; Wang, X; Agarwal, A; Deshpande, M; Phadke, AS Amide compounds for treatment of complement mediated disorders US Patent  US9695205 Publication Date 7/4/2017 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM111076
Synonyms:
US9695205, 54
Type:
Small organic molecule
Emp. Form.:
C31H27ClF2N6O6S
Mol. Mass.:
685.097
SMILES:
NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)c2cc(ccc12)C(=O)NS(=O)(=O)C1CC1 |r|
Structure:
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