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Target
Histamine H3 receptor
Ligand
BDBM108273
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
5.6±0.0 nM
Citation
 Gao, Z; Hall, D; Hartung, R Substituted piperidine spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof US Patent  US8604046 Publication Date 12/10/2013 
Target
Name:
Histamine H3 receptor
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
43426.88
Organism:
Macaca mulatta (Rhesus macaque)
Description:
G7N499
Residue:
390
Sequence:
MLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGNTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAGGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAAGAEAGETALGGGGGGGTAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEQCWK
  
Inhibitor
Name:
BDBM108273
Synonyms:
US8604046, 53
Type:
Small organic molecule
Emp. Form.:
C30H46N4O
Mol. Mass.:
478.7124
SMILES:
CC1CCCN1C1CCN(C1)c1ccc(N2CCC3(CCN(CC4CCCC4)CC3)C2=O)c(C)c1
Structure:
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