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Target
Urea transporter 1
Ligand
BDBM115187
Substrate
n/a
Meas. Tech.
UT-B Inhibition Assay
IC50
2.7e+4±n/a nM
Citation
 Esteva-Font, C; Phuan, PW; Anderson, MO; Verkman, AS A small molecule screen identifies selective inhibitors of urea transporter UT-A. Chem Biol 20:1235-44 (2013) [PubMed]  Article 
Target
Name:
Urea transporter 1
Synonyms:
Slc14a1 | UT11 | UT1_RAT | UT3 | Urea transporter B (UT-B)
Type:
Protein
Mol. Mass.:
42037.85
Organism:
Rattus norvegicus (Rat)
Description:
n/a
Residue:
384
Sequence:
MEDIPTMVKVDRGESQILSCRGRRCGLKVLGYVTGDMKEFANWLKDKPVVLQFMDWILRGISQVVFVSNPISGILILAGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYNATLVGILMAVFSDKGDYFWWLIFPVSAMSMTCPVFSSALSSLFSKWDLPVFTLPFNMALSLYLSATGHYNTFFPSKLFMPVSSVPNITWSELSALELLKSLPVGVGQIYGCDNPWTGAIFLCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFKDIYSGLWGFNSSLACIAIGGMFMALTWQTHLLALACALFTAYFGACMTHLMAAVHLPACTWSFCLATLLFLLLTTENPNIYRMPLSKVTYSEENRIFYLQNKKRVVDSPL
  
Inhibitor
Name:
BDBM115187
Synonyms:
N‐(3‐chloro‐4‐methoxyphenyl)‐8‐methoxy‐2‐ (thiomorpholine‐4‐carbonyl)quinolin‐4‐amine | UT-A1 inhibitor A6
Type:
Small organic molecule
Emp. Form.:
C22H22ClN3O3S
Mol. Mass.:
443.946
SMILES:
COc1ccc(Nc2cc(nc3c(OC)cccc23)C(=O)N2CCSCC2)cc1Cl
Structure:
Search PDB for entries with ligand similarity: