Reaction Details Report a problem with these data
Target
Prolyl hydroxylase EGLN2
Ligand
BDBM118333
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
780±n/a nM
Citation
 Thede, K; Flamme, I; Oehme, F; Ergüden, J; Stoll, F; Schuhmacher, J; Wild, H; Kolkhof, P; Beck, H; Keldenich, J; Akbaba, M; Jeske, M Substituted dihydropyrazolones for treating cardiovascular and hematological diseases US Patent  US8653111 Publication Date 2/18/2014 
Target
Name:
Prolyl hydroxylase EGLN2
Synonyms:
EGLN2 | EGLN2_HUMAN | EIT6 | Egl nine homolog 2 | Estrogen-induced tag 6 | HIF prolyl hydroxylase | HIF-PH1 | HIF-prolyl hydroxylase 1 | HPH-3 | Hypoxia-inducible factor prolyl hydroxylase | PHD1 | Prolyl hydroxylase domain-containing protein 1 | Prolyl hydroxylase domain-containing protein 1 (PHD1)
Type:
Protein
Mol. Mass.:
43657.01
Organism:
Homo sapiens (Human)
Description:
Q96KS0
Residue:
407
Sequence:
MDSPCQPQPLSQALPQLPGSSSEPLEPEPGRARMGVESYLPCPLLPSYHCPGVPSEASAGSGTPRATATSTTASPLRDGFGGQDGGELRPLQSEGAAALVTKGCQRLAAQGARPEAPKRKWAEDGGDAPSPSKRPWARQENQEAEREGGMSCSCSSGSGEASAGLMEEALPSAPERLALDYIVPCMRYYGICVKDSFLGAALGGRVLAEVEALKRGGRLRDGQLVSQRAIPPRSIRGDQIAWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGSYVINGRTKAMVACYPGNGLGYVRHVDNPHGDGRCITCIYYLNQNWDVKVHGGLLQIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEVKPAYATRYAITVWYFDAKERAAAKDKYQLASGQKGVQVPVSQPPTPT
  
Inhibitor
Name:
BDBM118333
Synonyms:
US8653111, 45
Type:
Small organic molecule
Emp. Form.:
C14H16N6O2
Mol. Mass.:
300.3158
SMILES:
CC(C)c1cn(nn1)-c1c[nH]n(-c2ccc(CO)cn2)c1=O
Structure:
Search PDB for entries with ligand similarity: