Reaction Details Report a problem with these data
Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A]
Ligand
BDBM285622
Substrate
n/a
Meas. Tech.
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays
IC50
21.0±n/a nM
Citation
 Chappie, TA; Patel, NC; Hayward, MM; Helal, CJ; Sciabola, S; LaChapelle, EA; Young, JM; Verhoest, PR Imidazopyridazine compounds US Patent  US10077269 Publication Date 9/18/2018 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A]
Synonyms:
DPDE4 | PDE4B | PDE4B1 | PDE4B_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70253.85
Organism:
Homo sapiens (Human)
Description:
Q07343[122-736,S654A]
Residue:
615
Sequence:
ATFPGHSQRREEFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQAMIPQAPAPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
  
Inhibitor
Name:
BDBM285622
Synonyms:
3-(4-cyano-2,5-difluorophenyl)-N-cyclopropylimidazo[1,2-b]pyridazine-2-carboxamide | US10077269, Example 92 | US10669279, Example 92 | US9598421, Example 92
Type:
Small organic molecule
Emp. Form.:
C17H11F2N5O
Mol. Mass.:
339.2989
SMILES:
Fc1cc(-c2c(nc3cccnn23)C(=O)NC2CC2)c(F)cc1C#N |(2.79,1.73,;1.31,1.33,;.91,-.16,;-.58,-.56,;-.98,-2.04,;-.07,-3.29,;-.98,-4.54,;-2.44,-4.06,;-3.78,-4.83,;-5.11,-4.06,;-5.11,-2.52,;-3.78,-1.75,;-2.44,-2.52,;1.47,-3.29,;2.24,-1.96,;2.24,-4.62,;3.78,-4.62,;5.11,-5.39,;5.11,-3.85,;-1.67,.53,;-3.16,.13,;-1.27,2.02,;.21,2.51,;.59,4.01,;.97,5.5,)|
Structure:
Search PDB for entries with ligand similarity: