Reaction Details Report a problem with these data
Target
Purine nucleoside phosphorylase
Ligand
BDBM136313
Substrate
n/a
Meas. Tech.
Inhibition Assay
Temperature
298.15±n/a K
Kd
51±n/a nM
Comments
extracted
Citation
 Clinch, K; Evans, GB; Furneaux, RH; Gulab, SA; Kelly, PM; Schramm, VL; Tyler, PC; Woolhouse, AD Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases US Patent  US8853224 Publication Date 10/7/2014 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Inhibitor
Name:
BDBM136313
Synonyms:
US8853224, 19
Type:
Small organic molecule
Emp. Form.:
C12H18N4O3S
Mol. Mass.:
298.361
SMILES:
CSC[C@H](O)[C@@H](O)CNCc1c[nH]c2c1nc[nH]c2=O
Structure:
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