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Target
Alpha-glucosidase MAL12
Ligand
BDBM152494
Substrate
n/a
Meas. Tech.
alpha-Glucosidase Assay
IC50
1.83e+4± 5.6e+2 nM
Citation
 Rahim, F; Malik, F; Ullah, H; Wadood, A; Khan, F; Javid, MT; Taha, M; Rehman, W; Ur Rehman, A; Khan, KM Isatin based Schiff bases as inhibitors of a-glucosidase: Synthesis, characterization, in vitro evaluation and molecular docking studies. Bioorg Chem 60:42-8 (2015) [PubMed]  Article 
Target
Name:
Alpha-glucosidase MAL12
Synonyms:
α-Glucosidase | MAL12 | MAL12_YEAST | MAL1S | Maltase | alpha-Glucosidase (α-Glucosidase)
Type:
Protein
Mol. Mass.:
68084.32
Organism:
Saccharomyces cerevisiae
Description:
P53341
Residue:
584
Sequence:
MTISDHPETEPKWWKEATIYQIYPASFKDSNNDGWGDLKGITSKLQYIKDLGVDAIWVCPFYDSPQQDMGYDISNYEKVWPTYGTNEDCFELIDKTHKLGMKFITDLVINHCSTEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSFFGGSAWTFDETTNEFYLRLFASRQVDLNWENEDCRRAIFESAVGFWLDHGVDGFRIDTAGLYSKRPGLPDSPIFDKTSKLQHPNWGSHNGPRIHEYHQELHRFMKNRVKDGREIMTVGEVAHGSDNALYTSAARYEVSEVFSFTHVEVGTSPFFRYNIVPFTLKQWKEAIASNFLFINGTDSWATTYIENHDQARSITRFADDSPKYRKISGKLLTLLECSLTGTLYVYQGQEIGQINFKEWPIEKYEDVDVKNNYEIIKKSFGKNSKEMKDFFKGIALLSRDHSRTPMPWTKDKPNAGFTGPDVKPWFLLNESFEQGINVEQESRDDDSVLNFWKRALQARKKYKELMIYGYDFQFIDLDSDQIFSFTKEYEDKTLFAALNFSGEEIEFSLPREGASLSFILGNYDDTDVSSRVLKPWEGRIYLVK
  
Inhibitor
Name:
BDBM152494
Synonyms:
(E)-2-(2,4-dichlorophenyl)-N'-(2-oxo-1-propylindolin-3-ylidene)acetohydrazide (2)
Type:
Small organic molecule
Emp. Form.:
C19H17Cl2N3O2
Mol. Mass.:
390.263
SMILES:
CCCN1C(=O)\C(=N\NC(=O)Cc2ccc(Cl)cc2Cl)c2ccccc12
Structure:
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