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Target
Histone deacetylase 1
Ligand
BDBM213185
Substrate
n/a
Meas. Tech.
HDAC Enzyme Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
23±n/a nM
Comments
extracted
Citation
 van Duzer, JH; Mazitschek, R; Jones, SS; Yang, M; Tamang, DL Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors US Patent  US9278963 Publication Date 3/8/2016 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM213185
Synonyms:
US9278963, 030
Type:
Small organic molecule
Emp. Form.:
C28H33N5O3
Mol. Mass.:
487.5933
SMILES:
CC(C)C[C@@H](C(=O)N1CCC(CC1)(Nc1ncc(cn1)C(=O)NO)c1ccccc1)c1ccccc1 |r|
Structure:
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