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Target
Histone deacetylase 2
Ligand
BDBM213161
Substrate
n/a
Meas. Tech.
HDAC Enzyme Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
24±n/a nM
Comments
extracted
Citation
 van Duzer, JH; Mazitschek, R; Jones, SS; Yang, M; Tamang, DL Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors US Patent  US9278963 Publication Date 3/8/2016 
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM213161
Synonyms:
US9278963, 008
Type:
Small organic molecule
Emp. Form.:
C24H26N6O4
Mol. Mass.:
462.501
SMILES:
COc1ccc(NC(=O)N2CCC(CC2)(Nc2ncc(cn2)C(=O)NO)c2ccccc2)cc1
Structure:
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