Reaction Details
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Genome polyprotein [2420-3010]
Ligand
BDBM246468
Substrate
n/a
Meas. Tech.
NS5B RNA Polymerase Assay
pH
7.5±n/a
IC50
1.4e+3± 1e+2 nM
Comments
extracted
Citation
Deshpande, M; Wiles, JA; Hashimoto, A; Phadke, A Highly active nucleoside derivative for the treatment of HCV US Patent US9447132 Publication Date 9/20/2016 More Info.:
Target
Name:
Genome polyprotein [2420-3010]
Synonyms:
POLG_HCVCO | RNA polymerase (NS5B) | RNA-directed RNA polymerase (NS5B)
Type:
Enzyme
Mol. Mass.:
65783.36
Organism:
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
Description:
aa 2420-3010
Residue:
591
Sequence:
SMSYTWTGALITPCAAEETKLPINALSNSLLRHHNLVYATTSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSARSKFGYGAKDVRNLSSKAVNHIRSVWKDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPGQRVEFLVNAWKAKKCPMGFAYDTRCFDSTVTENDIRVEESIYQCCDLAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAAAACRAAKLQDCTMLVCGDDLVVICESAGTQEDEASLRAFTEAMTRYSAPPGDPPKPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIQRLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVRTKLKLTPIPAASQLDLSSWFVAGYSGGDIYHSLSRARPRWFMWCLLLLSVGVGIYLLPNR
Inhibitor
Name:
BDBM246468
Synonyms:
US9447132, Formula IV
Type:
Small organic molecule
Emp. Form.:
C10H17N2O15P3
Mol. Mass.:
498.1677
SMILES:
C[C@@]1(O)[C@H](O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)OC1n1ccc(=O)[nH]c1=O |r|
Structure:
