Reaction Details Report a problem with these data
Target
Genome polyprotein [2420-3010]
Ligand
BDBM249179
Substrate
n/a
Meas. Tech.
Cell-Based HCV Replicon Assay
Temperature
321.15±n/a K
EC50
>100000±n/a nM
Comments
extracted
Citation
 Girijavallabhan, V; Bogen, S; Pan, W; Dang, Q; Davies, I 2′-disubstituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases US Patent  US9457039 Publication Date 10/4/2016 
Target
Name:
Genome polyprotein [2420-3010]
Synonyms:
POLG_HCVBK | RNA-directed RNA polymerase (NS5B)
Type:
Enzyme
Mol. Mass.:
65648.71
Organism:
Hepatitis C virus genotype 1b (isolate BK) (HCV)
Description:
aa 2420-3010
Residue:
591
Sequence:
SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRSAGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQYSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCDLAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKASAACRAAKLQDCTMLVNGDDLVVICESAGTQEDAASLRVFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASRLDLSGWFVAGYSGGDIYHSLSRARPRWFMLCLLLLSVGVGIYLLPNR
  
Inhibitor
Name:
BDBM249179
Synonyms:
US9457039, 2
Type:
Small organic molecule
Emp. Form.:
C12H15N7O3
Mol. Mass.:
305.2926
SMILES:
C[C@@]1(N=[N+]=[N-])[C@H](O)[C@@H](CO)O[C@H]1c1ccc2c(N)ncnn12 |r|
Structure:
Search PDB for entries with ligand similarity: