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Target
Genome polyprotein [2420-3010]
Ligand
BDBM249192
Substrate
n/a
Meas. Tech.
Cell-Based HCV Replicon Assay
Temperature
321.15±n/a K
EC50
>100000±n/a nM
Comments
extracted
Citation
 Girijavallabhan, V; Bogen, S; Pan, W; Dang, Q; Davies, I 2′-disubstituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases US Patent  US9457039 Publication Date 10/4/2016 
Target
Name:
Genome polyprotein [2420-3010]
Synonyms:
POLG_HCVBK | RNA-directed RNA polymerase (NS5B)
Type:
Enzyme
Mol. Mass.:
65648.71
Organism:
Hepatitis C virus genotype 1b (isolate BK) (HCV)
Description:
aa 2420-3010
Residue:
591
Sequence:
SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRSAGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQYSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCDLAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKASAACRAAKLQDCTMLVNGDDLVVICESAGTQEDAASLRVFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASRLDLSGWFVAGYSGGDIYHSLSRARPRWFMLCLLLLSVGVGIYLLPNR
  
Inhibitor
Name:
BDBM249192
Synonyms:
US9457039, 16 | US9457039, 17
Type:
Small organic molecule
Emp. Form.:
C17H26N5O5P
Mol. Mass.:
411.3926
SMILES:
CC(C)(C)COP1(=O)OC[C@H]2O[C@@H](c3ccc4c(N)ncnn34)[C@](C)(N)[C@@H]2O1 |r|
Structure:
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