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Target
Adenosine receptor A2b
Ligand
BDBM415450
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
2.70±n/a nM
Citation
 Härter, M; Kosemund, D; Delbeck, M; Kalthof, B; Wasnaire, P; Süβmeier, F; Lustig, K Heterocyclylmethyl-thienouracile as antagonists of the adenosine-A2B-receptor US Patent  US10428083 Publication Date 10/1/2019 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM415450
Synonyms:
3-Isopropyl-1-(2-methoxyethyl)-5-methyl-6-[(2-oxoimidazolidin-1-yl)methyl]thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione | US10428083, Example 86
Type:
Small organic molecule
Emp. Form.:
C17H24N4O4S
Mol. Mass.:
380.462
SMILES:
COCCn1c2sc(CN3CCNC3=O)c(C)c2c(=O)n(C(C)C)c1=O
Structure:
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