Reaction Details Report a problem with these data
Target
Proteinase-activated receptor 4
Ligand
BDBM454806
Substrate
n/a
Meas. Tech.
FLIPR Assay in PAR4-Expressing HEK293 Cells
IC50
0.500±n/a nM
Citation
 Fu, Q; Zhang, X; Priestley, ES; Halpern, OS; Reznik, SK; Richter, JM Bicyclic heteroaryl substituted compounds US Patent  US10730868 Publication Date 8/4/2020 
Target
Name:
Proteinase-activated receptor 4
Synonyms:
Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3
Type:
Protein
Mol. Mass.:
41145.16
Organism:
Homo sapiens (Human)
Description:
Q96RI0
Residue:
385
Sequence:
MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
  
Inhibitor
Name:
BDBM454806
Synonyms:
US10730868, Ex. No. 73
Type:
Small organic molecule
Emp. Form.:
C28H24FN5O5S
Mol. Mass.:
561.584
SMILES:
COc1ccc(NC(=O)O[C@@H]2CC[C@@H]2Oc2cc3sc(nc3cc2F)-c2cc(C)cc3nc(OC)cnc23)cn1 |r|
Structure:
Search PDB for entries with ligand similarity: