Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM464581
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
2.30±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793556 Publication Date 10/6/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM464581
Synonyms:
CIS-4-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-butyramide | US10793556, Example SC_4001
Type:
Small organic molecule
Emp. Form.:
C25H38N4O2
Mol. Mass.:
426.5948
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CCCC(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:3.2,6.17,(7.13,-2.65,;7.9,-3.98,;9.44,-3.98,;7.13,-5.31,;6.36,-6.65,;4.82,-6.65,;4.05,-5.31,;3.14,-4.07,;1.68,-4.54,;.59,-3.46,;-.9,-3.85,;-1.99,-2.77,;-3.48,-3.16,;-4.57,-2.08,;-3.88,-4.65,;1.68,-6.08,;.43,-6.99,;3.14,-6.56,;3.62,-8.03,;2.59,-9.17,;1.05,-9.17,;1.05,-10.71,;2.59,-10.71,;4.82,-3.98,;6.36,-3.98,;7.9,-6.65,;7.13,-7.98,;7.9,-9.32,;9.44,-9.32,;10.21,-7.98,;9.44,-6.65,)|
Structure:
Search PDB for entries with ligand similarity: