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Target
Nociceptin receptor
Ligand
BDBM469884
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
0.800±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469884
Synonyms:
CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[2-(1,1-dioxo-[1,4]thiazinan-4-yl)-2- oxo-ethyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one | US10807989, Example SC_1113
Type:
Small organic molecule
Emp. Form.:
C27H40N4O4S
Mol. Mass.:
516.696
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)N3CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.23,3.2,(15.69,4.95,;16.08,3.47,;17.57,3.07,;15,2.38,;14.23,1.04,;12.69,1.04,;11.92,2.38,;11.01,3.62,;9.55,3.15,;8.21,3.92,;6.88,3.15,;6.88,1.61,;5.54,3.92,;5.54,5.46,;4.21,6.23,;2.88,5.46,;1.54,4.69,;2.48,6.95,;2.88,3.92,;4.21,3.15,;9.55,1.61,;8.21,.84,;11.01,1.13,;11.41,-.36,;10.32,-1.44,;8.78,-1.44,;8.78,-2.98,;10.32,-2.98,;12.69,3.71,;14.23,3.71,;16.33,1.61,;16.33,.07,;17.66,-.7,;19,.07,;19,1.61,;17.66,2.38,)|
Structure:
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